Salesforce ( CRM ) stock is on course for its worst one-day loss since 2004, hurting the Dow Jones Industrial Average and a batch of exchange-traded funds (ETFs) with meaningful exposure to the company or to the Dow.

Shares fell Thursday after the customer relationship management company reported fiscal first-quarter revenue that came in lower than analysts’ estimates, and provided management guidance that was also weaker than expected.

The Dow fell more than 400 points before pulling back a little, sending ETFs tracking the Dow trending lower.

The SPDR Dow Jones Industrial Average ETF ( DIA ), the largest ETF tracking the 30-stock index with more than $32 billion in assets, fell 0.7% Thursday. Salesforce is the ETF’s seventh-largest holding, comprising about 4.64% of its portfolio.

Salesforce’s Plunge Hurts Some Tech ETFs

A big loser Thursday was the iShares Expanded Tech-Software Sector ETF ( IGV ), which has an 8% holding in Salesforce . The ETF has around $6 billion in assets, according to company data, and was down more than 5%. The SPDR Technology Select Sector SPDR ( XLK ) was lower by 2%, and has 2.7% exposure to the company. That ETF is more heavily exposed to Microsoft ( MSFT ) and Apple ( AAPL ), with holdings of around 20% in each.

Another big decliner Thursday was the $5.2 billion First Trust Dow Jones Internet Index Fund ( FDN ), which focuses on the technology components of the Dow. The fund was trading down 3% in reflection of a 4.88% exposure to Salesforce stock.